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Muscle insulin signaling and hepatic insulin action in MCK-IL10 and WT mice fed standard or HFD for 3 weeks. A: Insulin-stimulated tyrosine phosphorylation of IRS-1 and IRS-1 protein levels in skeletal muscle (gastrocnemius). B: Hepatic insulin action. Values are means ± SE for four to six mice in each experimental group. *P < 0.05 vs. WT mice fed standard or HFD. A two-way ANOVA was used for statistical analysis.
