TABLE 2.

Genomic context and association test results for the three SNPs associated with fasting blood glucose levels among Indian Asians in the Hap610 sample at P < 5 × 10⁻⁸

Genomic context			Alleles		Risk allele frequency		Indian Asians					European Caucasians
							Hap610 sample		Hap300 sample		Combined analysis
SNP	Chr	Gene locus	Alt	Risk	IA	EC	Effect	P	Effect	P	P	Effect	P
rs2166706	11	MTNR1B	A	G	46.2	45.0	0.07 (0.04–0.09)	1.6 × 10−8	0.05 (0.01–0.08)	0.006	2.1 × 10−9	0.05 (0.03–0.07)	4.9 × 10−7
rs3847554	11	MTNR1B	G	A	49.8	49.4	0.06 (0.04–0.09)	1.9 × 10−8	0.04 (0.01–0.08)	0.01	3.9 × 10−9	0.06 (0.04–0.08)	2.5 × 10−8
rs1387153	11	MTNR1B	G	A	38.1	35.3	0.06 (0.04–0.09)	3.5 × 10−8	0.05 (0.01–0.08)	0.01	1.5 × 10−8	0.05 (0.03–0.07)	2.6 × 10−7

Data are effect size (95% CI) for fasting glucose in millimoles per liter for each copy of the risk allele. All three SNPs were directly genotyped, with call rates >99% in the three study samples. Alt, alternate allele; Chr, chromosome; EC, European Caucasian; IA, Indian Asian.