TABLE 1.
Baseline clinical characteristics of the GoKinD collection
| GoKinD collection |
P | ||
|---|---|---|---|
| Control subjects | Case subjects | ||
| n | 885 | 820 | |
| Men/women | 363/522 | 423/397 | <0.0001 |
| Age at type 1 diabetes diagnosis (years) | 12.9 ± 7.4 | 11.8 ± 6.7 | 0.0008 |
| Duration of type 1 diabetes (years)* | 25.4 ± 7.8 | 26.5 ± 7.7 | 0.003 |
| Age at examination (years) | 38.3 ± 8.7 | 43.1 ± 6.9 | <0.0001 |
| Laser treatment (%) | 17 | 85 | <0.0001 |
| A1C (%)† | 7.4 ± 1.2 | 8.3 ± 1.6 | <0.0001 |
| ACR (μg/mg) | |||
| Control subjects | 6.5 ± 3.7 | ||
| Proteinuric subjects | 1,520 ± 1,478 | ||
| Systolic blood pressure (mmHg) | 117.6 ± 11.9 | 131.1 ± 18.9 | <0.0001 |
| Diastolic blood pressure (mmHg) | 71.4 ± 7.8 | 74.3 ± 10.8 | <0.0001 |
| Case subjects with proteinuria/ESRD | — | 284/536 | |
| ESRD duration (years) | — | 7.3 ± 5.5 | |
| Kidney transplant (%)‡ | — | 92 | |
Data are means ±SD unless otherwise indicated.
*The duration of type 1 diabetes in control and proteinuric subjects is based on the duration at examination. Among ESRD case subjects, this is based on the duration of type 1 diabetes at the onset of ESRD. All other clinical characteristics are based on measurements performed at examination.
†Mean A1C values do not include data from case subjects that have undergone pancreas transplantation (32%).
‡Percentages are of ESRD group.