FIG. 3.

Cardiac histopathology in diabetic db/db and nondiabetic db/m mice with or without dRK6 treatment (Trichrome stain, ×100). The histopathology shows marked cardiac fibrosis in diabetic db/db-dRK6 (D) compared with nondiabetic db/m and db/m-dRK6 mice (A and B) and db/db control mice (C). Original magnification ×200. Quantitative assessment of the areas of fibrosis in the myocardial tissue of the study groups (E). *P < 0.01 compared with the other groups; n = 4. (A high-quality color digital representation of this figure is available in the online issue.)