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. 2009 Aug 12;58(11):2666–2676. doi: 10.2337/db09-0136

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© 2009 American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Immunofluorescent staining for HIF-1α in the heart. Representative pictures illustrating expression in nondiabetic db/m (A), db/m-dRK6 (B), diabetic db/db (C), and db/db-dRK6 mice (D) in myocytes. Original magnification ×200. E: Quantitative assessment of HIF-1α immunoreactivity in the myocardial cells in diabetic db/db and nondiabetic db/m mice with or without dRK6 treatment. **P < 0.001 compared with the other groups. F: Expression of HIF-1α protein, mRNA, and 18s rRNA in the hearts of the study groups. Quantitative assessment of the expression of HIF-1α mRNA (G) and protein (H). *P < 0.05, **P < 0.01 compared with the other groups, ^#P < 0.01 compared with the db/db group; n = 4. Immunohistochemical expression of 8-OH-dG protein in myocardial cells. In diabetic db/db mice (K), 8-OH-dG protein is markedly accentuated in the myocardium (dark nucleus) compared with nondiabetic db/m and db/db-dRK6 mice (I and J, respectively). More prominent 8-OH-dG immunostaining is seen in the db/db-dRK6 mice compared with the diabetic db/db mice (L). Original magnification ×200. M: Quantitative assessment of 8-OH-dG levels in the DNA from the hearts. *P < 0.05, compared with db/m, **P < 0.01 compared with db/m and P < 0.05 compared with db/m-dRK6 and db/db; n = 4. (A high-quality color digital representation of this figure is available in the online issue.)