TABLE 1.

Influence of dRK6 on physiologic and biochemical parameters and serum lipid profiles in db/db and db/m mice

	db/m	db/m-RK6	db/db	db/db-RK6
Body weight (g)	31.6 ± 1.2	31.2 ± 1.3	50.3 ± 5.8*	42.4 ± 5.9*
Heart weight (g)	0.12 ± 0.04	0.11 ± 0.05	0.12 ± 0.04	0.14 ± 0.05
Mean SBP (mmHg)	95.6 ± 5.4	97.6 ± 3.5	99.1 ± 6.2	102.3 ± 5.0
Hematocrit (%)	34.0 ± 2.9	35.6 ± 3.4	39.8 ± 5.2	38.6 ± 6.4
Glucose (mmol/l)	11.2 ± 1.1	11.8 ± 1.9	58.0 ± 5.9†	57.6 ± 7.8†
A1C (%)	4.3 ± 0.2	4.1 ± 0.3	12.7 ± 1.2†	13.6 ± 1.0†
Total cholesterol (mmol/l)	1.66 ± 0.38	1.53 ± 0.34	2.08 ± 0.37	1.92 ± 0.31
Triglycerides (mg/dl)	60 ± 16	66 ± 20	103 ± 27‡	114 ± 21‡
FFAs (mEq/l)	1.45 ± 0.34	1.57 ± 0.55	3.18 ± 1.03‡	3.76 ± 1.19‡
Insulin (pg/ml)	0.17 ± 0.13	0.19 ± 0.14	0.50 ± 0.14‡	0.33 ± 0.21‡
Serum VEGF (pg/ml)	1.25 ± 1.73	23.5 ± 7.7§	6.6 ± 3.9‡	29.6 ± 8.5§

Data are means ± SD.

*P < 0.01,

†P < 0.001,

‡P < 0.05 vs. dm and dm-dRK6.

§P < 0.001 vs. dm and P < 0.05 vs. db/db.