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. 2009 Aug 18;58(11):2536–2546. doi: 10.2337/db08-1361

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© 2009 American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — High-fat feeding induces inflammation in heart. A: Plasma IL-6 and TNF-α levels were elevated in HFD-fed mice. ■, Standard diet; , HFD. B: Immunohistochemistry using anti-CD68 of heart samples obtained after HFD or standard (chow) diet. CD68 markers, shown with red arrows, are elevated in HFD heart. C: Quantification of immunohistochemical CD68 levels. D: Macrophage-specific CD68 protein levels normalized to β-actin in heart was elevated in HFD-fed mice. E: TLR4 and MyD88 expression normalized to β-actin were elevated in HFD heart. F: SOCS3 protein levels normalized to β-actin were increased in heart following HFD. Values are means ± SE for five to seven mice in each experiment. *P < 0.05 vs. standard diet–fed mice. (A high-quality color digital representation of this figure is available in the online issue.)

Inline graphic — High-fat feeding induces inflammation in heart. A: Plasma IL-6 and TNF-α levels were elevated in HFD-fed mice. ■, Standard diet; , HFD. B: Immunohistochemistry using anti-CD68 of heart samples obtained after HFD or standard (chow) diet. CD68 markers, shown with red arrows, are elevated in HFD heart. C: Quantification of immunohistochemical CD68 levels. D: Macrophage-specific CD68 protein levels normalized to β-actin in heart was elevated in HFD-fed mice. E: TLR4 and MyD88 expression normalized to β-actin were elevated in HFD heart. F: SOCS3 protein levels normalized to β-actin were increased in heart following HFD. Values are means ± SE for five to seven mice in each experiment. *P < 0.05 vs. standard diet–fed mice. (A high-quality color digital representation of this figure is available in the online issue.)