FIG. 7.
IL-6 deletion attenuates diet-induced inflammatory response in heart. A: Immunofluorescence staining specific for Tyr705 phosphorylation of STAT3 was increased in wild-type (WT) heart but not in IL-6 KO heart following HFD without changes in total STAT3 levels. B: Quantification of phospho-STAT3 normalized to total STAT3 protein levels. C: Macrophage-specific CD68 levels normalized to β-actin in heart were lower in HFD-fed IL-6 KO mice. D: SOCS3 protein levels normalized to β-actin were reduced in IL-6 KO heart following HFD. Values are means ± SE for four to seven mice in each experimental group. *P < 0.05 vs. wild-type mice. (A high-quality color digital representation of this figure is available in the online issue.)