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. 2009 Aug 18;58(11):2536–2546. doi: 10.2337/db08-1361

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© 2009 American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 8. — Acute lipid infusion induces inflammation and suppresses AMPK in heart. Intralipid emulsion plus heparin or glycerol (control) were intravenously infused for 5 h in C57BL/6 mice, and heart samples were taken for analysis. A: Plasma FFA levels were increased by 3.5-fold following lipid infusion. B and C: Local IL-6 and TNF-α levels in heart were elevated in lipid-infused mice. D–F: Acute lipid infusion increased inflammation and macrophage-specific CD68, CCR2, and MyD88 levels in heart. All proteins were normalized to β-actin. G: Myocardial SOCS3 levels normalized to β-actin tended to be higher following lipid infusion. H and I: Total AMPK protein levels normalized to β-actin and Thr¹⁷²-phosphorylation of AMPK normalized to total AMPK protein levels were reduced in heart following lipid infusion. Values are means ± SE for 6–11 mice in each experiment. *P < 0.05 vs. control.