Table 1.
Baseline and 1-year postinfusion characteristics of autologous umbilical cord blood recipients (n = 8 male and 7 female)
| Preinfusion | 1-year postinfusion | (Preinfusion-to–1 year postinfusion ratio) −1 | P vs. baseline | |
|---|---|---|---|---|
| Age (years) | 5.5 (3.1–7.3) | — | — | — |
| Time from diagnosis to infusion (months) | 4.1 (2.5–7.1) | — | — | — |
| A1C (%) | 7.0 (6.1–8.3) (15) | 7.0 (6.5–7.7) (15) | 0.035 (−0.07 to 0.125) (15) | 0.45 |
| Insulin use (units · kg−1 · day−1) | 0.42 (0.21–0.55) (15) | 0.67 (0.55–0.77) (15) | 0.52 (0.00–1.56) (15) | 0.0085 |
| Peak C-peptide (ng/ml) | 0.93 (0.7–2.03) (14) | 0.50 (0.26–1.30) (12) | −0.53 (−0.72 to −0.32) (12) | 0.0024 |
| IA-2 | 9.5 (1.8–20.6) (11) | 9.8 (0.7–14.47) (9) | −0.48 (−0.58 to −0.10) (8) | 0.20 |
| GAD | 4.2 (0.9–11.4) (13) | 3.5 (0.45–33.5) (12) | −0.44 (−0.63 to 0.34) (11) | 0.52 |
| WBC (cell × 109/l) | 5.5 (4.9–7.3) (14) | 4.9 (4.2–6.3) (14) | −0.13 (−0.29 to 0.14) (14) | 0.031 |
| CD4-to-CD8 ratio | 2.0 (1.7–2.6) (14) | 1.9 (1.6–2.2) (12) | −0.03 (−0.13 to 0.11) (12) | 0.86 |
| Peripheral blood Treg (%) | 5.4 (2.4–7.0) (12) | 5.0 (4.1–7.2) (13) | 0.31 (−0.06 to 2.00) (11) | 0.12 |
Data are median (IQR) (n). IA-2, insulinoma-associated protein 2 autoantibody; WBC, white blood cell count.