Table 1.
Relationship between retinal vascular Df and incident diabetic retinopathy
| Retinal vascular Df | n | Incidence per 100 person-years | Model 1* |
Model 2† |
Model 3‡ |
|||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |||
| Right eye only | ||||||||
| Quartile 1 (≤1.4497) | 132 | 10.7 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | |||
| Quartile 2 (1.4498–1.4628) | 132 | 9.1 | 0.84 (0.56–1.26) | 0.39 | 0.80 (0.52–1.21) | 0.29 | 0.82 (0.53–1.26) | 0.36 |
| Quartile 3 (1.4629–1.4738) | 132 | 10.4 | 0.97 (0.65–1.46) | 0.89 | 0.95 (0.62–1.45) | 0.80 | 0.97 (0.63–1.49) | 0.88 |
| Quartile 4 (≥1.4739) | 133 | 10.3 | 0.95 (0.63–1.45) | 0.82 | 0.90 (0.58–1.40) | 0.64 | 0.93 (0.60–1.45) | 0.75 |
| Ptrend | 0.84 | 0.75 | 0.82 | |||||
| Right and left eyes combined§ | ||||||||
| Quartile 1 (≤1.4471) | 279 | 10.8 | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | |||
| Quartile 2 (1.4472–1.4598) | 278 | 9.3 | 0.89 (0.67–1.18) | 0.41 | 0.88 (0.65–1.19) | 0.41 | 0.90 (0.66–1.21) | 0.47 |
| Quartile 3 (1.4599–1.4730) | 266 | 10.3 | 0.98 (0.74–1.30) | 0.89 | 0.98 (0.73–1.32) | 0.88 | 0.99 (0.73–1.33) | 0.93 |
| Quartile 4 (≥1.4731) | 257 | 9.5 | 0.91 (0.67–1.22) | 0.52 | 0.92 (0.68–1.26) | 0.92 | 0.95 (0.69–1.30) | 0.74 |
| Ptrend | 0.82 | 0.84 | 0.89 | |||||
*Model 1 adjusted for age and sex.
†Model 2 adjusted for age, sex, diabetes duration, A1C, mean arterial blood pressure, BMI, and total cholesterol.
‡Model 3 adjusted for variables in model 2 as well as central retinal arteriolar equivalent and central retinal venular equivalent.
§Analysis performed using the generalized estimation equation model.