Table 2.
Association of Depression and Antidepressant Use With Lower Spine Bone Mineral Density (g/cm2) for Entire Sample
| Model 1 |
Model 2 |
Model 3 |
||||
|---|---|---|---|---|---|---|
| Variable | Coefficient (95% CI) |
p Value | Coefficient (95% CI) |
p Value | Coefficient (95% CI) |
p Value |
| Lifetime MDD (ref. Never) | −0.134 (−0.238, −0.029) |
.012 | −0.109 (−0.197, −0.022) |
.014 | −0.140 (−0.230, −0.049) |
.003 |
| Lifetime antidepressant use (ref. Never) | — | 0.052 (−0.121, 0.226) |
.554 | 0.067 (−0.073, 0.205) |
.354 | |
| Sex × Antidepressant use (ref. Male, Never use) | — | −0.204 (−0.402, −0.008) |
.042 | −0.218 (−0.398, −0.029) |
.017 | |
Notes: Model 1 is adjusted for age, race, and sex. Model 2 is adjusted for Model 1 plus lifetime antidepressant use and lifetime antidepressant use × sex. Model 3 is adjusted for Model 2 plus calcium use, smoking status, alcohol use, Physical Activity Scale for the Elderly score, and total percent fat. N = 94 for all models.
CI = confidence interval; MDD = major depressive disorder.