Table 3.
Association of Depression and Antidepressant Use With Lower Spine Bone Mineral Density (g/cm2) Stratified by Sex
| Model 1 |
Model 2 |
Model 3 |
||||
|---|---|---|---|---|---|---|
| Variable | Coefficient (95% CI) |
p Value | Coefficient (95% CI) |
p Value | Coefficient (95% CI) |
p Value |
| Women | ||||||
| Lifetime MDD (ref. Never) | −0.180 (−0.299, −0.060) |
.003 | −0.132 (−0.244, −0.021) |
.020 | −0.162 (−0.285, −0.039) |
.010 |
| Lifetime antidepressant use (ref. Never use) | −0.156 (−0.266, −0.047) |
.005 | −0.141 (−0.263, −0.020) |
.023 | ||
| Men | ||||||
| Lifetime MDD (ref. Never) | 0.005 (−0.157, 0.166) |
.955 | −0.035 (−0.205, 0.136) |
.691 | −0.106 (−0.267, 0.056) |
.199 |
| Lifetime antidepressant use (ref. Never use) | 0.094 (−0.087, 0.274) |
.308 | 0.073 (−0.086, 0.232) |
.366 | ||
Notes: For women (N = 63): Model 1 is adjusted for age and race. Model 2 is adjusted for Model 1 plus lifetime antidepressant use. Model 3 is adjusted for Model 2 plus calcium use, total percent fat, and lifetime estrogen use. For men (N = 31): Model 1 is adjusted for age and race. Model 2 is adjusted for Model 1 plus lifetime antidepressant use. Model 3 is adjusted for Model 2 plus smoking status, alcohol use, Physical Activity Scale for the Elderly score, and total percent fat.
CI = confidence interval; MDD = major depressive disorder.