Figure 1. Results of Tests for the Association between Stroke and Each SNP Measured in the Genomewide Association Study.
P values (based on the fixed-effects model) are shown in signal-intensity (Manhattan) plots relative to their genomic position for total stroke (Panel A) and ischemic stroke (Panel B). Within each chromosome, the results are plotted left to right from the p-terminal end. The top horizontal line indicates the chosen threshold for genomewide significance, P = 5×10−8; the middle line indicates the threshold for P = 10−5; and the bottom line indicates the threshold for P = 10−4.