Table 4. Measured Parameters of Ventilation and Gas Exchange at Rest and Exercise*.
| Variables | Control Subjects (n = 47) |
EOV Patients (n = 47) |
p Value† |
|---|---|---|---|
| Rest | |||
| V̇o2, mL/kg/min | 3.9 ± 1.2 | 4.1 ± 1.1 | 0.34 |
| V̇co2, L/min | 0.31 ± 0.11 | 0.31 ± 0.11 | 0.99 |
| V̇e, L/min | 12 ± 4.2 | 14 ± 5.1 | 0.23 |
| Vt, L | 0.79 ± 0.51 | 0.72 ± 0.29 | 0.84 |
| fb, breaths/min | 17 ± 4.7 | 20 ± 4.4 | < 0.001 |
| Petco2, mm Hg | 33 ± 3.3 | 31 ± 4.3‡ | 0.02 |
| V̇e/V̇co2 | 40 ± 4.7 | 45 ± 7.5 | 0.002 |
| 50% peak exercise | |||
| V̇o2, mL/kg/min | 10 ± 2.9 | 8.6 ± 3.0 | 0.005 |
| V̇co2, L/min | 0.71 ± 0.25 | 0.61 ± 0.22 | 0.04 |
| V̇e, L/min | 24 ± 7.5 | 25 ± 8.7 | 0.84 |
| Vt, L | 1.1 ± 0.4 | 1.0 ± 0.3 | 0.03 |
| fb, breaths/min | 21 ± 4.7 | 26 ± 5.8 | < 0.001 |
| Petco2, mm Hg | 35 ± 4.0 | 31 ± 4.5 | < 0.001 |
| V̇e/V̇co2 | 34 ± 5.6 | 41 ± 6.8 | < 0.001 |
| Peak exercise | |||
| V̇o2, mL/kg/min | 20 ± 7.5 | 16 ± 5.2 | 0.01 |
| V̇co2, L/min | 1.9 ± 0.87 | 1.4 ± 0.56 | 0.01 |
| V˙e, L/min | 61 ± 25 | 57 ± 20 | 0.66 |
| Vt, L | 1.9 ± 0.7 | 1.7 ± 0.6 | 0.06 |
| fb, breaths/min | 32 ± 5.5 | 35 ± 7.1 | 0.08 |
| Petco2, mm Hg | 34 ± 5.3 | 30 ± 5.0‡ | < 0.001 |
| V̇e/V̇co2 | 34 ± 6.6 | 40.2 ± 7.8 | < 0.001 |
| RER | 1.1 ± 0.12 | 1.1 ± 0.13 | 0.08 |
*
Values are given as the mean ± SD, unless otherwise indicated. fb = breathing frequency; RER = respiratory exchange ratio
†
Determined by t test.
‡
p = 0.03 for comparison of Petco2 (within group) from rest to peak exercise.