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. 2009 Sep 1;101(8):1448–1455. doi: 10.1038/sj.bjc.6605277

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Copyright © 2009 Cancer Research UK

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Nuclear factor of activated T-cells (NFAT) transcriptional activity, mRNA expression and protein expression in melanoma cell lines. (A) NFAT transcriptional activity measured in three human metastatic melanoma cell lines. BRAF mutational status is indicated for reference. Values are means from four independent experiments carried out in triplicate (± s.e.m.). (B) NFAT mRNA expression in primary melanocytes and in three metastatic melanoma cell lines as determined by real-time qPCR. Values are mean 2^−ΔCt from RNA derived from two independent cultures (± s.d.). (C) Western blots indicate the expression of three previously described NFAT2 isoforms, NFAT3 protein and NFAT4 protein. 1°=primary melanocytes, CHL=CHL-1 cells, WM=WM266-4 cells. Equal protein loading was confirmed by blotting for β-actin. Statistical analysis in (A) performed by one-way ANOVA, ^* P⩽0.05, ^** P⩽0.01, ^*** P⩽0.001.