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. 2009 Oct 13;101(8):1469–1480. doi: 10.1038/sj.bjc.6605275

Figure 1.

Figure 1

(A) Dendrogram resulting of unsupervised hierarchical clustering of the 14 BRCA1 tumours and 5570 genes that remained after data quality filtering. Two main clusters are observed mediated by ESR1 expression (left branch encompasses tumours over-expressing ESR1 and right branch those with modest or no detectable levels of ESR1). (B) Unsupervised hierarchical clustering of the 14 BRCA1 tumours using the transcript levels of 55 genes representing markers of the five distinct subclasses of sporadic breast tumours (Perou et al, 2000). The same clusters as in the previous analysis are observed except for sample #33.