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. 2009 Oct 13;101(8):1469–1480. doi: 10.1038/sj.bjc.6605275

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Copyright © 2009 Cancer Research UK

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Unsupervised hierarchical clustering obtained with 94 genes differentially expressed in the ESR1-negative tumours, using the Bonferroni correction, in 18 BRCA1 and two BRCA2 (#99 and #94) tumours from the external series of van ‘t Veer et al (2002). Clustering of tumours according to the presence or not of lymphocytic infiltrate and angioinvasion is observed. Relevant genes of breast cancer metastasis and those that more strongly differentiate clusters are shown. Pathological characteristics are annotated as shown in the inset and follow-up times (months) are shown at the bottom. Expression values are represented as log2 ratios.