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. 2009 Oct 16;15:2050–2060.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cu²⁺-induced structural changes of αA- and G98R αA-crystallin. Far-UV (A) and near-UV (B) CD spectra of 1 mg/ml of αA-crystallin (curve 1) and G98R αA-crystallin (curve 2) and of 150 μM Cu²⁺-treated samples of αA-crystallin (curve 3) and G98R αA-crystallin (curve 4) in buffer B are shown. C: Changes in the mean hydrodynamic radii (R_h) of 0.5 mg/ml αA-crystallin and G98R αA-crystallin in the absence (open bars) and in the presence of 75 μM of Cu²⁺ (filled bars) were determined by dynamic light scattering studies. The error bars represent the statistical variations of the mean hydrodynamic radii of αA-crystallin or mutant αA-crystallin between 10 experimental data. G98R αA-crystallin is more susceptible to the Cu²⁺-induced structural changes compared to αA-crystallin. [θ]_MRM, mean residue mass ellipticity.