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. Author manuscript; available in PMC: 2009 Oct 27.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1809–1815. doi: 10.1161/hq1101.097805

Figure 4.

Figure 4

Atherosclerotic lesions in huLPL+ and huLPL− mice. huLPL+/apoE KO and huLPL−/apoE KO mice were maintained on a Western atherogenic diet for 8, 13, or 17 weeks. A, Representative photomicrographs from aortic sinus region of huLPL+/apoE KO and huLPL−/apoE KO male mice they had been fed a Western diet for 13 weeks. Lesion and luminal areas were traced and the areas measured with imaging software. B, Lesion areas for males and females after being fed a Western diet for 8 weeks are represented as percentage of total luminal area of that particular section. Each point represents a unique section from the aortic sinus region of a different animal. C, Lesion area was measured in serial sections starting from the aortic sinus region and proceeding away from the heart. Results for male huLPL+/apoE KO (closed circles) or huLPL−/apoE KO (open squares) mice after 3 weeks on a Western diet are shown.