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. Author manuscript; available in PMC: 2009 Oct 27.
Published in final edited form as: Leuk Res. 2007 Jan 23;31(8):1145–1148. doi: 10.1016/j.leukres.2006.12.006

Figure 1. Breakapart FISH analysis of interphase cells from a patient with de novo RAEB-I, demonstrating rearrangement of MLL.

Figure 1

Red probe corresponds to the 5′ end of MLL, whereas the green probe corresponds to the 3′ end of MLL. Intact MLL is associated with an overlapping red/green (i.e., yellow) fusion signal. In this case, each cell demonstrates separation of one set of the red and green probes, corresponding to a translocation involving MLL.