Table.
Case Number |
Age (y) and Sex |
Diagnosis |
MLL- SEPT9 Variant* |
Clinical Outcome |
Reference |
---|---|---|---|---|---|
1 | 10 F | t-AML** | 1 | NR | (9) |
2 | 24 M | AML M4*** | 1 | Death without achieving remission |
(10) |
3 | 4 months F | De novo AML M5 | 1 | Alive >5 years with multiagent chemotherapy followed by cord blood transplant |
(10) |
4 | 64 M | De novo AML M4 | 1 | Septic death during relapse after brief chemotherapy- induced remission |
(11) |
5 | 8 M | De novo AML M4 | 3 | NR | (5) |
6 | 60 F | De novo AML M5 | 2 | NR | (5) |
7 | 50 F | De novo AML M2 | 1 | NR | (5) |
8 | 61 F | MDS (unclassifiable, then RAEB-I) |
3 | Clinical response to decitabine, referred for stem cell transplantation |
This report |
Abbreviations: M, male; F, female; y, years of age; AML, acute myeloid leukemia; t-AML, therapy-related AML; MDS, myelodysplastic syndrome; NR, not reported.
See Figure 1B.
Following therapy for Hodgkin disease.
Patient was previously treated for AML M2 with t(8;21) AML1-ETO fusion.