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. Author manuscript; available in PMC: 2010 Mar 6.
Published in final edited form as: J Mol Biol. 2009 Mar 6;386(4):1066–1077. doi: 10.1016/j.jmb.2009.01.012

Figure 5. The kinase activity of Ala scanning mutants in region 1.

Figure 5

A. The N-lobe of Src catalytic domain. The seven-residue fragment, W260 through S266 studied in this experiment is indicated. B. The kinase activity of Src-Csk chimeric kinase C8 and designated Ala scanning mutants based on C8 are shown. All the activities are expressed as a percentage of that of C8. C. Interaction between R264 and the β-4.5 turn by four hydrogen bonds.