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. Author manuscript; available in PMC: 2010 Mar 1.

Published in final edited form as: Lancet Oncol. 2009 Feb 7;10(3):247–257. doi: 10.1016/S1470-2045(09)70002-6

Table 5.

Multivariate Cox regression analyses for overall and progression-free survival, including rash and diarrhea as predictor variables (n=46^a)

	Overall Survival			Progression-free Survival
Variable	HR	95% CI	p-value	HR	95% CI	p-value
Disease type:
Met^b	1.18	(0.52, 2.68)	0.70	1.50	(0.70. 3.19)	0.29
Both^b	1.97	(0.80, 4.83)	0.14	2.83	(1.14, 7.06)	0.025
Second-line	3.87	(1.77, 8.47)	0.0007	2.43	(1.21, 4.87)	0.0012
Diarrhea^c	0.28	(0.13, 0.64)	0.0023	0.57	(0.28, 1.19)	0.57
Rash^d	1.49	(0.71, 3.13)	0.29	1.17	(0.58, 2.34)	0.66

SE: standard error; HR: hazard ratio; Met: metastatic; Both: local/regional recurrence and metastatic disease

^a

Two patients had missing data

^b

Relative to local/advanced disease only

^c

Grade 1 or higher vs. 0

^d

Grade 2 or higher vs. 0/1