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Metabolism and anabolic phosphorylation of CDV, (S)-HPMPA and their HDP esters in MRC-5 cells in vitro
Legend: 10 μM 14C-labeled CDV, (S)-HPMPA, HDP-CDV and HDP-(S)-HPMPA were applied to wells containing confluent MRC-5 cells and incubated for 24 hrs. Anabolic phosphorylation to their monophosphates (CDVp and (S)-HPMPAp) and diphosphates (CDVpp and (S)-HPMPApp) was measured by Partisil SAX HPLC. Adapted from Aldern et al, 2003, and Magee et al, 2008.
