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Stimulus-response relations and pain mechanisms. A representation of the relationship between external noxious and innocuous stimuli and the sensory responses they evoke, depending on which afferent fiber is activated (nociceptor or low-threshold neuron) and whether the sensitivity of either the peripheral nervous system (PNS) or the central nervous system (CNS) is disturbed to amplify the response to stimuli (sensitization) and generate ectopic impulses.
