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. Author manuscript; available in PMC: 2009 Oct 27.
Published in final edited form as: J Cell Sci. 2008 Sep 15;121(Pt 18):3071–3082. doi: 10.1242/jcs.031575

Fig. 3.

Fig. 3

c-Abl and its PxxP motif interaction partners modulate Rac1 activity during attachment. NIH3T3 cells overexpressing CrkII, Nck2, c-Abl or 1234 (A), STI-571 treated, or Crk or Nck family knockdown NIH3T3 cells (B) were harvested in suspension or 5 minutes after attachment on 4 μg/ml fibronectin-coated dishes. Whole cell lysates (WCL) were subjected to GTPase assay, and the amounts of Rac1 and Cdc42 were detected by western blotting.