Table 1.
SH3 domains binding to Abl PxxP motifs identified by screening a phage display library containing all known human SH3 domains. Details are described in Materials and Methods and (Karkkainen et al., 2006).
Abl PxxP motifs used for bait (Functional PxxP motifs) | Protein bound | SH3 domain (Total # of SH3 domains) | Hit/Total # of Colony Examined |
---|---|---|---|
WT (123) | Crk | 1st (2) | 4/4 |
12 (3) | Nck1 | 2nd (3) | 2/7 |
12 (3) | Ponsin | 3rd (3) | 2/7 |
12 (3) | ArgBP2 | 3rd (3) | 1/7 |
12 (3) | Crk | 1st (2) | 1/7 |
12 (3) | CrkL | 1st (2) | 1/7 |
3 (12) | Crk | 1st (2) | 6/6 |