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. 2009 Oct 30;5(10):e1000552. doi: 10.1371/journal.pcbi.1000552

Figure 4. Effect of truncation on the accessible hydrophobic surface of a kinase domain.

Figure 4

(A) Theoretical and actual values for the accessible nonpolar surface area (Anp) of a cyclin-dependent kinase. The C-terminus of the protein structure was gradually truncated and the actual values of Anp (full magenta circles) for the truncated fragments were determined with the CHASA program [22]. They coincide with the theoretical values for an intact domain of the same size (blue contiguous line) around residue 90. (B) Structure of the cyclin-dependent kinase (PDB code 1g3n, chain A). The C-terminal portion missing due to the translocation is colored grey.