Table 2.

Model 1. Cognitive Decline as Predictors of Mortality, without Adjustment for Dementia (covariates include: age, sex, education, depression, recruitment status [volunteer vs. random], general and a specific cognitive function at baseline).

Cognitive Domains^*	Overall		Age 65 – 74		Age 75 – 84
Cognitive Domains^*	HR (95% CI)	Significant covariates	HR (95% CI)	Significant covariates	HR (95% CI)	Significant covariates
General cognition decline	2.2^§ (1.7–2.8)	Age^§	2.6^§ (1.6–4.4)	Volunteer^‡	2.2^§ (1.7–2.8)	Age^§
		Female^‡		Baseline general cognition^‡		Female^§
		Volunteer^§
Memory composite decline	2.6^† (1.2–5.9)	Age^§	31.9^§ (6.3–160.9)	Volunteer^‡	NS	Age^§, female^‡
		Volunteer^‡		Baseline memory^†		Higher education^‡
		Baseline memory^§				Baseline memory^§
Learning composite decline	2.4^† (1.1–4.7)	Age^§	8.5^‡ (1.9–37.4)	Volunteer^‡	NS	Age^§, female^‡
		Volunteer^‡		Baseline learning^†		Higher education^‡
		Baseline learning^§				Baseline learning^§
Visuospatial composite decline	NS	Age^§	3.2^† (1.1–9.5)	Volunteer^‡	NS	Age^§, female^§
		Female^§		Baseline visuospatial^‡		Higher education^†
		Volunteer^‡				Baseline visuospatial^§
		Baseline visuospatial^§
Language composite decline	4.1^§ (2.3–7.3)	Age^§	6.5^‡ (1.9–22.9)	Volunteer^‡	3.1^§ (1.6–6.0)	Age^§
		Female^‡		Baseline language^†		Female^§
		Volunteer^‡
		Baseline language^‡
Executive composite decline	7.5^§ (2.6–20.8)	Age^§	35.1^§ (5.9–206.9)	Volunteer^‡	NS	Age^§
		Female^‡		Baseline executive^§		Female^§
		Higher education^‡				Higher education^‡
		Volunteer^‡				Baseline executive^‡
		Baseline executive^§
Processing speed decline	6.6^§ (3.1–13.4)	Age^§	NS	Volunteer^†	7.4^§ (3.3–16.4)	Age^§
		Female^†				Female^‡
		Volunteer^‡				Baseline speed^§
		Baseline speed^§

Separate model fit for average annual decline in each domain; model also adjusts for baseline score in that domain.

^†

p<0.05;

^‡

p<0.01;

^§

p<0.001; Bonferroni correction for multiple comparisons p < 0.005