Table 3.

Model 2. Cognitive Decline as Predictors of Mortality, with Adjustment for Dementia (additional covariates include: age, sex, education, depression, recruitment status [volunteer vs. random], general and specific cognitive function at baseline).

Cognitive Domains*	Overall		Age 65 – 74		Age 75 – 84
	HR (95% CI)	Significant covariates	HR (95% CI)	Significant covariates	HR (95% CI)	Significant covariates
General cognition decline	1.9‡ (1.5–2.4)	Age§, Female‡	2.0† (1.1–3.6)	Volunteer‡	1.8§ (1.4–2.4)	Age§
		Volunteer‡		Baseline general cognition†		Female§
		Dementia‡				Dementia‡
Memory composite decline	NS	Age§	23.5‡ (3.6–153.6)	Volunteer‡	NS	Age§, female‡
		Female†				Higher education†
		Volunteer‡				Dementia§
		Dementia§				Baseline memory†
Learning composite decline	NS	Age§	NS	Volunteer‡	NS	Age§, female‡
		Volunteer‡		Baseline learning†		Higher education†
		Dementia§				Dementia§
		Baseline learning‡				Baseline learning†
Visuospatial composite decline	NS	Age§	NS	Volunteer‡	NS	Age§, female§
		Female§		Dementia†		Higher education†
		Volunteer‡		Baseline visuospatial†		Dementia§
		Baseline visuospatial§				Baseline visuospatial§
Language composite decline	2.6‡ (1.4–5.1)	Age§	NS	Volunteer‡	NS	Age§
		Female‡		Baseline language†		Female§
		Volunteer‡				Dementia§
		Dementia‡
		Baseline language†
Executive composite decline	4.5‡ (1.5–13.4)	Age§, Female‡	21.8‡ (3.2–147.8)	Volunteer‡	NS	Age§
		Higher education†		Baseline executive‡		Female§
		Volunteer‡				Higher education‡
		Dementia‡				Dementia‡
		Baseline executive§				Baseline executive†
Processing speed decline	4.2§ (2.0–9.2)	Age§	NS	Volunteer‡	5.3§ (2.2–12.6)	Age§
		Female‡		Baseline speed‡		Female‡
		Volunteer‡				Dementia†
		Dementia‡				Baseline speed§
		Baseline speed§

^*Separate model fit for average annual decline in each domain; model also adjusts for baseline score in that domain.

^†p<0.05;

^‡p<0.01;

^§ p<0.001; Bonferroni correction for multiple comparisons p < 0.005