Table 1.
Conditioned Medium were Analyzed Using Anti-body Arrays
| Control | 1% Tob | 2% Tob | 4% Tob | |
|---|---|---|---|---|
| sTNF Rll | ++ | + | +/− | +/− |
| IGFBP3 | − | − | − | + |
| uPAR | − | − | − | + |
| Angiogenin | − | − | − | − |
| GCSF | − | − | − | − |
| RANTES | +/− | +/− | +/− | +/− |
| GRO | − | − | +/− | + |
| IL-1ra | + | + | ++ | ++ |
| bFGF | − | − | + | + |
| MIP-1a | + | + | + | + |
| ICAM-1 | − | − | − | + |
| Osteoprotegerin | − | + | + | + |
| IGFBP4 | + | ++ | +++ | ++ |
| IL-6 | + | + | + | +++ |
| MCP-1 | +/− | + | ++ | ++ |
| TIMP-1 | + | ++ | ++ | ++ |
| IL-8 | +/− | ++ | ++ | ++ |
| TIMP-2 | + | +++ | +++ | +++ |
NOTE: Secreted proteins significantly up-regulated by Tob are designated +, ++, or +++ (also indicated by progressively darker shading), whereas proteins showing little or no change are designated +/− or −.