Table 2.
Baseline details of the 865 ICSI cycles.
|
hMG (n = 299) |
HP-hMG (n = 330) |
r-hFSH (n = 236) |
p value | |
| Mean age, years (± SD) | 32.5 (± 5.3)a | 34.0 (± 4.7)b | 34.3 (± 4.8)c | < 0.001 (a vs b, c) |
| ≤35 years, n (%) | 213 (71.2)a | 198 (60.0)b | 142 (60.2)c | 0.005 (a vs b, c) |
| >35 years, n (%) | 86 (28.8)a | 132 (40.0)b | 94 (39.8)c | 0.005 (a vs b, c) |
| Indication, n (%) | ||||
| Male factor only | 111 (37.1) | 99 (30.0) | 76 (32.2) | 0.27 |
| Mixed factor* | 142 (47.5) | 156 (47.3) | 129 (54.7) | 0.19 |
| Female factor | 46 (15.4) | 75 (22.7) | 31 (13.1) | 0.33 |
| Treatment cycle, n (%) | ||||
| 1st cycle | 195 (65.3) | 192 (58.1) | 145 (61.4) | 0.49 |
| 2nd cycle | 80 (26.7) | 86 (26.0) | 60 (25.4) | 0.83 |
| ≥3rd cycle | 24 (8.0) | 52 (15.9) | 31 (13.2) | 0.34 |
| Mean baseline FSH, IU/L (± SD) | 6.3 (± 3.2) | 6.7 (± 3.7) | 6.5 (± 2.8) | 0.33 |
| ≤35 years | 6.0 (± 2.8) | 6.5 (± 3.1) | 6.1 (± 3.0) | 0.23 |
| >35 years | 7.2 (± 3.9) | 7.2 (± 4.4) | 7.3 (± 4.7) | 0.69 |
| Mean baseline LH, IU/L (± SD) | 4.9 (± 4.1) | 5.4 (± 4.4) | 5.2 (± 3.7) | 0.23 |
| ≤35 years | 5.2 (± 4.4) | 5.2 (± 4.1) | 5.1 (± 3.9) | 0.63 |
| >35 years | 4.2 (± 3.0)a | 5.8 (± 4.8)b | 4.3 (± 3.9)c | 0.004 (b vs a, c) |
Distribution by menotropin (hMG), highly-purified menotropin (HP-hMG) or follitropin alfa (r-hFSH), after pituitary down-regulation, in relation to the age, indication, baseline FSH and LH levels, and total number of treated cycles.
*Mixed factor: male + female.
FSH, follicle stimulating hormone; hMG, human menopausal gonadotropin; HP-hMG, highly-purified hMG; ICSI, intracytoplasmic sperm injection; LH, luteinizing hormone; r-hFSH, recombinant human FSH; SD, standard deviation.