Table 3.
Clinical and laboratory outcomes of COH during the 865 ICSI cycles.
|
hMG (n = 299) |
HP-hMG (n = 330) |
r-hFSH (n = 236) |
p value | |
| Mean length of stimulation, days (± SD) | 9.6 (± 1.3)a | 10.0 (± 1.3)b | 10.1 (± 1.0)c | < 0.001 (a vs b, c) |
| ≤35 years | 9.5 (± 1.3)a | 9.9 (± 1.2)b | 10.0 (± 0.9)c | < 0.001 (a vs b, c) |
| >35 years | 9.8 (± 1.4)a | 10.2 (± 1.6)b | 10.2 (± 1.1)c | 0.007 (a vs b, c) |
| Gonadotropin dose adjustment, n (%) | 56 (18.7)a | 67 (20.3)b | 126 (53.4)c | < 0.001 (c vs a, b) |
| ≤35 years | 43 (20.1)a | 47 (23.7)b | 90 (63.3)c | < 0.001 (c vs a, b) |
| >35 years | 13 (15.1)a | 20 (15.1)b | 36 (38.2)c | < 0.001 (c vs a, b) |
| Mean estradiol on day of hCG, pg/mL (± SD) | 1967.0 (± 1241.0)a |
2479.0 (± 1708.0)b |
2159.3 (± 1411.7)c | 0.001 (a vs b, c) |
| ≤35 years | 2174.8 (± 1224.4)a |
2609.3 (± 1632.0)b |
2392.3 (± 1422.3)c |
0.035 (a vs b) |
| >35 years | 1432.7 (± 1124.6)a |
2285.1 (± 1804.4)b |
1789.1 (± 1325.7)c |
0.001 (a vs b) |
| Cancellation rate, n (%) | 23 (7.7) | 21 (6.4) | 17 (7.2) | 0.80 |
| ≤35 years | 10 (4.7) | 9 (4.5) | 10 (7.0) | 0.50 |
| >35 years | 13 (15.1) | 12 (9.0) | 7 (7.4) | 0.20 |
| Severe OHSS, n (%) | 7 (2.3) | 6 (1.8) | 3 (1.3) | 0.76 |
| ≤35 years, n | 5 | 4 | 3 | - |
| >35 years, n | 2 | 2 | 0 | - |
| Mean number of retrieved oocytes, n (± SD) | 10.9 (± 6.8) | 10.7 (± 6.5) | 10.8 (± 6.7) | 0.97 |
| ≤35 years | 12.3 (± 6.7) | 11.3 (± 5.5) | 11.7 (± 6.0) | 0.50 |
| >35 years | 7.5 (± 5.8) | 9.7 (± 7.6) | 9.5 (± 7.5) | 0.08 |
| Mean MII oocytes, n (± SD) | 8.9 (± 5.6) | 8.9 (± 5.7) | 8.7 (± 5.6) | 0.82 |
| ≤35 years | 10.1 (± 5.5) | 9.4 (± 4.8) | 9.1 (± 5.0) | 0.20 |
| >35 years | 5.8 (± 4.4)a | 8.3 (± 6.8)b | 8.1 (± 6.3)c | 0.01 (a vs b, c) |
| Fertilization rate 2PN, % (± SD) | 72 (± 25) | 72 (± 22) | 71 (± 23) | 0.83 |
| ≤35 years | 71 (± 22) | 72 (± 22) | 72 (± 22) | 0.76 |
| >35 years | 73 (± 30) | 72 (± 24) | 70 (± 25) | 0.20 |
| Top quality embryos on day3, % (± SD) | 40 (± 30)a | 47 (± 31)b | 39 (± 29)c | 0.004 (b vs a, c) |
| ≤35 years | 41 (± 29)a | 47 (± 28)b | 39 (± 28)c | 0.03 (b vs a, c) |
| >35 years | 39 (± 34) | 48 (± 34) | 37 (± 30) | 0.08 |
| Mean number of transferred embryos, n (± SD) | 3.4 (± 1.6) | 3.4 (± 1.5) | 3.2 (± 1.6) | 0.18 |
| ≤35 years | 3.5 (± 1.4) | 3.5 (± 1.4) | 3.2 (± 1.4) | 0.05 |
| >35 years | 2.9 (± 1.9) | 3.1 (± 1.6) | 3.2 (± 1.8) | 0.50 |
Distribution by menotropin (hMG), highly-purified menotropin (HP-hMG) or follitropin alfa (r-hFSH) for COH. Overall and age-stratified outcomes are presented.
2PN, two pronuclei; COH, controlled ovarian hyperstimulation; human chorionic gonadotropin; hMG, human menopausal gonadotropin; HP-hMG, highly-purified hMG; ICSI, intracytoplasmic sperm injection; MII, metaphase II; OHSS, ovarian hyperstimulation syndrome; r-hFSH, recombinant human follicle-stimulating hormone; SD, standard deviation.