Table 5.
Clinical and laboratory outcomes of COH in ICSI cycles with clinical pregnancy during the 865 cycles.
|
hMG (n = 106) |
HP-hMG (n = 132) |
r-hFSH (n = 82) |
p value | |
| Mean age, years (± SD) | 31.1 (± 5.0)a | 32.7 (± 4.2)b | 32.8 (± 4.2)c | 0.01 (a vs b, c) |
| ≤35 years (± SD) | 29.2 (± 3.6)a | 30.7 (± 3.1)b | 30.8 (± 2.9)c | 0.004 (a vs b, c) |
| >35 years (± SD) | 38.3 (± 1.9)a | 37.0 (± 2.0)b | 37.3 (± 1.6)c | 0.04 (a vs b, c) |
| Mean length of stimulation, days (± SD) | 9.6 (± 1.3)a | 9.8 (± 1.0)b | 10.0 (± 1.0)c | 0.01 (a vs b, c) |
| ≤35 years | 9.5 (± 1.3)a | 9.9 (± 1.0)b | 10.0 (± 0.9)c | 0.001 (a vs b, c) |
| >35 years | 10.1 (± 1.3)a | 9.7 (± 1.0)b | 9.9 (± 1.0)c | 0.66 |
| Mean baseline FSH, IU/L (± SD) | 6.0 (± 2.4) | 6.5 (± 3.7) | 6.3 (± 2.2) | 0.63 |
| ≤35 years | 5.8 (± 2.2) | 6.2 (± 2.9) | 6.0 (± 2.0) | 0.51 |
| >35 years | 6.6 (± 3.2) | 7.1 (± 5.0) | 7.1 (± 4.5) | 0.91 |
| Mean baseline LH, IU/L (± SD) | 5.6 (± 5.3) | 5.5 (± 3.7) | 5.2 (± 3.0) | 0.90 |
| ≤35 years | 5.7 (± 5.6) | 5.5 (± 4.0) | 5.3 (± 4.1) | 0.89 |
| >35 years | 5.2 (± 3.5) | 5.4 (± 2.7) | 5.5 (± 3.1) | 0.70 |
| Mean estradiol on day of hCG, pg/mL (± SD) | 2102.8 (± 1207.4)a |
2682.9 (± 1440.7)b |
2488.0 (± 1630.7)c | 0.005 (a vs b) |
| ≤35 years | 2225.5 (± 1221.0)a |
2753.3 (± 1402.3)b |
2742.9 (± 1716.8)c |
0.01 (a vs b, c) |
| >35 years | 1605.7 (± 1036.6) |
2510.7 (± 1537.5) |
1850.9 (± 1203.6) |
0.06 |
| Mean number of retrieved oocytes, n (± SD) | 12.1 (± 6.6) | 12.2 (± 6.1) | 12.4 (± 6.8) | 0.92 |
| ≤35 years | 13.0 (± 6.7) | 12.4 (± 5.2) | 12.3 (± 5.9) | 0.92 |
| >35 years | 8.7 (± 5.1) | 11.5 (± 8.0) | 12.5 (± 9.0) | 0.25 |
| Mean MII oocytes, n (± SD) | 9.7 (± 4.8) | 10.3 (± 5.5) | 9.9 (± 5.5) | 0.67 |
| ≤35 years | 10.6 (± 4.8) | 10.3 (± 4.6) | 9.7 (± 4.6) | 0.20 |
| >35 years | 6.4 (± 3.1) | 10.1 (± 7.3) | 10.6 (± 7.3) | 0.05 |
| Fertilization rate 2PN, % (± SD) | 77 (± 17) | 76 (± 17) | 75 (± 18) | 0.71 |
| ≤35 years | 74 (± 17) | 74 (± 17) | 75 (± 17) | 0.91 |
| >35 years | 88 (± 12) | 79 (± 18) | 76 (± 19) | 0.07 |
| Top quality embryos on day3, % (± SD) | 47 (± 28)a | 55 (± 28)b | 41 (± 25)c | 0.004 (b vs a, c) |
| ≤35 years | 49 (± 26)a | 54(± 28)b | 40 (± 26)c | 0.02 (b vs c) |
| >35 years | 40 (± 32)a | 60 (± 29)b | 44 (± 22)c | 0.02 (b vs a, c) |
| Mean number of transferred embryos, n (± SD) | 3.9 (± 1.0) | 3.8 (± 0.9) | 3.6 (± 0.9) | 0.65 |
| ≤35 years | 3.4 (± 1.0) | 3.6 (± 0.9) | 3.5 (± 0.9) | 0.79 |
| >35 years | 4.0 (± 0.9) | 4.0 (± 0.8) | 3.9 (± 0.9) | 0.33 |
Distribution by menotropin (hMG), highly-purified menotropin (HP-hMG) or follitropin alfa (r-hFSH) for COH. Overall and age-stratified outcomes are presented.
2PN, two pronuclei; COH, controlled ovarian hyperstimulation; FSH, follicle-stimulating hormone; hCG, human chorionic gonadotropin; hMG, human menopausal gonadotropin; HP-hMG, highly-purified hMG; ICSI, intracytoplasmic sperm injection; LH, luteinizing hormone; MII, metaphase II; r-hFSH, recombinant human FSH; SD, standard deviation.