Table 1. Characteristics of blank and pSOD-EYFP-encapsulated HSA NP formulations.
|
Formulation |
Size (nm) |
Polydispersity |
Zeta potential (mV) |
pSOD loading% |
| Blank HSA NP I* |
158±3 |
0.16±0.01 |
-20.4±0.9 |
- |
| pSOD-HSA NP I* |
157±1 |
0.09±0.01 |
-23.1±1.5 |
64.8±2.4 |
| Blank HSA NP II** |
116±7 |
0.29±0.04 |
-22.7±4.9 |
- |
| pSOD-HSA NP II** | 122±2 | 0.25±0.01 | -44.3±0.7 | 83.6±4.7 |
* Particles were prepared with 1 μl of 10% glutaraldehyde (low crosslinking). ** Particles were prepared with 20 μl of 10% glutaraldehyde (high crosslinking).