The contour plots show the average blood-to-fat signal ratio computed over a band of [−80 80] Hz around the water and fat resonances. The magnetization profiles for blood (T1/T2 = 1000/200 ms) and fat (T1/T2 = 270/85 ms) were simulated for a practically useful range of parameters: TR1 ∈ [2.5 4.5] ms, τ = TR3/TR1 ∈ [0.2 1], and three different flip angles: 30°, 45°, and 60°. The boundary conditions for the simulations were TR1 = TR2 and TR3 = TR4. The near-optimal values for the suppression ratio are achieved when τ is in the [0.4 0.65] range. The level of suppression improves at higher flip angles. Finally, the highest level of suppression is attained around TR1 ≈ 3.4 ms for α = 60°.