. Author manuscript; available in PMC: 2009 Oct 28.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2009 Jun 1;74(2):553–561. doi: 10.1016/j.ijrobp.2009.02.015

Table 5.

Relationship between HPV pyrosequencing signal intensity and other molecular markers

Parameters	All (%)	HPV negative-weak	HPV strong	p value
Median tumor pO₂ (mm Hg)
Mean value	14.0	13.3	15.5	0.43
CAIX
Negative	38 (46.3%)	19 (23.3%)	19 (23.2%)	0.44
Weak	30 (36.6%)	18 (22.0%)	12 (14.6%)
Strong	13 (15.8%)	9 (11.0%)	4 (4.9%)
Inevaluable	1 (1.2%)	0	1 (1.2%)
EGFR staining intensity
Negative	45 (54.9%)	17 (20.7%)	28 (34.1%)	0.0006
Weak	3 (3.7%)	1 (1.2%)	2 (2.4%)
Strong	29 (35.4%)	24 (29.3%)	5 (6.1%)
Inevaluable	5 (6.1%)	4 (4.9%)	1 (1.2%)
% cells staining positive for EGFR
0%–10%	47 (57.3%)	17 (20.7%)	30 (36.6%)	0.0002
11%–80%	16 (19.5%)	12 (14.6%)	4 (4.9%)
81%–100%	14 (17.0%)	13 (15.8%)	1 (1.2%)
Inevaluable	5 (6.1%)	4 (4.9%)	1 (1.2%)
CD3 staining intensity
Negative	4 (4.9%)	3 (3.7%)	1 (1.2%)	0.03
Weak	35 (42.7%)	24 (29.3%)	11 (13.4%)
Strong	40 (48.9%)	16 (19.5%)	24 (29.3%)
Inevaluable	3 (3.7%)	3 (3.7%)	0

Abbreviation: HPV = human papillomavirus.