Figure 3. Gene dosage alterations and outcome after chemoradiotherapy for patients with different tumor size.

(A) Kaplan-Meier curves of progression free survival for cervical cancer patients with tumor size above (green) and below (black) median. Ninety-two patients with tumor size determined from diagnostic MR images were included. Median size was 45.1 cm³, corresponding to a diameter of 4.4 cm. (B,C) Kaplan-Meier curves for patients in (A) with tumor size below median (B) and above median (C). Group 1: patients without loss of 3p11.2-p14.1, 13q13.1-q21.1, or 21q22.2-3, group 2: patients with loss of 3p11.2-p14.1 and/or 13q13.1-q21.1, but not 21q22.2-3, group 3: patients with loss of 21q22.2-3 only or loss of 21q22.2-3 combined with loss of 3p11.2-p14.1 and/or 13q13.1-q21.1. The groups were determined from data of each possible combination of the losses (Figure S3). P-values in log-rank test and number of patients are indicated.