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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Circ Heart Fail. 2009 Jul 21;2(5):472–481. doi: 10.1161/CIRCHEARTFAILURE.109.853200

Figure 5.

Figure 5

Panel A shows a representative chart recording during a potassium contracture where force and calcium were measured simultaneously. Panels B and C show representative force-calcium relationships (displayed pCa and normalized to max) that were derived from the potassium contractures. We observed a shift in myofilament calcium sensitivity from 1 to 4 Hz in the sham trabeculae and observed a blunted or no shift in sensitivity in the PAB trabeculae. Panel D shows the average pCa50 for 9 sham and 11 PAB animals. The only significant change in pCa50 between frequencies was between 1 and 4 Hz in the sham trabeculae (p<0.05, Two-way repeated measures ANOVA, followed by paired t-test). Panel D shows average max force for all steady state curves at 1 and 4 Hz in sham and PAB trabeculae. No significant difference was found between any of the groups.