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. 2009 Oct 26;206(11):2455–2467. doi: 10.1084/jem.20090805

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© 2009 Kunder et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — Injected granules traffic to the DLN and contain functional TNF. (A) Toluidine blue staining of DLN tissue sections from an MC-deficient Kit^W-sh/W-sh mouse injected with 9.0 × 10³ isolated MC-derived particles. Bar, 50 µm. (B) Same area as in A showing only metachromatic staining. The location of the edge of the DLN is depicted by a dashed line. (C) Magnification from square in A. Bar, 10 µm. (D) LN hypertrophy 24 h after injection of 1.5 × 10⁴ particles purified from WT or TNF^−/− mice (n = 3 for each group; *, P < 0.005 for the comparison between the two groups; data analyzed by unpaired two-tailed Student’s t test; error bars indicate standard error of the mean). All panels show results that are representative of two independent experiments.