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. 2009 Oct 26;206(11):2407–2416. doi: 10.1084/jem.20082286

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© 2009 Das et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Regulation of transcription factors in Th cells by TGF-β and IL-6. FACS-sorted CD25⁻CD62L^hiCD44^lo naive CD4⁺ T cells were activated with plate-bound anti-CD3 and anti-CD28 in the presence of 5 ng/ml TGF-β, 20 ng/ml IL-6, or both for 48 h. Anti–TGF-β was added at a concentration of 10 µg/ml. Expression levels of the transcription factors RORγt, GATA-3, Stat-6, Stat-4, and Tbx21 in the cells were determined by quantitative PCR. Results shown are representative of three independent experiments.