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. 2009 Oct 26;206(11):2381–2395. doi: 10.1084/jem.20091007

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© 2009 Decrem et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — Effect of Ir-CPI on pulmonary embolism model. (A) Mortality associated with i.v. of collagen and epinephrine after administration of PBS (vehicle) or Ir-CPI. All PBS-treated mice died within 5 min. Animals alive 30 min after the challenge were considered survivors. Data represent the mean ± SEM of the results obtained with 15 animals per group from two independent experiments. *, P ≤ 0.05. (B) Platelet counts in mice 2 min after infusion of collagen/epinephrine. The control group was not injected with collagen/epinephrine. Data represents the mean ± SEM of results obtained with five animals per group from two independent experiments. Values on the number of circulating platelets in the three groups of injected mice are significantly alike. (C) Number of thrombi in the lungs of mice 2 min after infusion of collagen/epinephrine. Thrombi per visual field were counted at 20×. Data represent the mean for 20 fields per mice (n = 3 per group) from two independent experiments.