Table II.

Hemostasis and coagulation in Ir-CPI–treated rats

Inhibitors	aPTT	PT	Fibrinolysis	Bleeding effect (O.D. 450 nm)
	s	s	min
PBS	20.0 ± 3.8	21.4 ± 1.5	53 ± 27	0.026 ± 0.006
Ir-CPI 0.1 mg/kg	20.7 ± 3.9	21.3 ± 1.1	66 ± 29	0.067 ± 0.060
Ir-CPI 1 mg/kg	28.8 ± 3.4a	21.6 ± 1.6	51 ± 28	0.021 ± 0.008
LMWH 0.5 mg/kg	36.2 ± 3.8a	26.9 ± 1.4a	57 ± 19	0.174 ± 0.091a

Values are mean ± SEM (n = 5 for each test). LMWH, low molecular weight heparin.

^aP < 0.05, as compared to values observed in the control (PBS) by one-way ANOVA and Student’s t test–Newman-Keuls test.