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Insulin-induced IFN resistance. Interaction between insulin and the PEG-interferon α-signaling pathway. PI3K activated by insulin seems to be responsible for the block of STAT1 translocation that avoids the antiviral effect of interferon. Dotted lines represent inhibition, continuous lines represent activation. IRS-2: Insulin substrate-2; 2',5'-OAS: 2',5'-oligoadenylate synthetase; PKR: Protein kinase.
