Table 2.
Angiogenic activity of plasma from tumor-bearing animals was due to TSP-1
| Primary tumor | Secreted TSP-1 | Positive corneas/total implanted
|
|||
|---|---|---|---|---|---|
| Tested alone | + bFGF | + anti-TSP | + bFGF and anti-TSP | ||
| none | none | 0/3 | 3/3 | nd | nd |
| HT-23 | low | 2*/3 | nd | 3*/3 | nd |
| HT1080 | high | 0/3 | 0/3 | 3*/3 | 3/3 |
Pellets containing plasma derived from tumor-bearing mice mixed with additives where indicated were implanted into avascular rat carneas and vigorous vessel ingrowth at 7 days and scored as a positive response.
*weakly angiogenic compared to bFGF-induced responses. nd, not determined.