Figure 5.

The expressions and RE-scores of microRNAs predicted to target Dicer. BL and MA represent the microRNA microarray data published by Blenkiron et al. [30] and Mattie et al. [32]. HE, MI, MN, VA and WA represent the mRNA microarray data published by Hess et al. [44], Miller et al. [38], Minn et al. [39], van't Veer et al. [34], and Wang et al. [40], which were used to calculate the microRNA RE-scores. If the difference between ER⁺ and ER^- samples is significant, the plot is flagged with three asterixes. The expression levels of these six microRNAs are mostly lower in ER^- samples; however, almost all the RE-scores in ER^- samples are higher, suggesting that the differential regulatory effects of miRNAs can not be explained by miRNA expression difference between ER⁺ and ER^- cancers.