Figure 6.

RE-score profiles of microRNAs for the classification of ER⁺ and ER^- breast tumors. The figure demonstrates unsupervised hierarchical clustering of 57 ER⁺ and 42 ER^- samples in the MN dataset [39] using the top 8 RE-changing miRNAs. A dendrogram of the tumors is shown at the top, with ER⁺ samples in red and ER^- samples in yellow. For hierarchical clustering, RE-scores of each miRNA were mean centered and normalized, and tumors were clustered using Pearson correlation (uncentered) and average linkage (CLUSTER and TREEVIEW software) [73].