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. 2009 Sep 1;10(9):R90. doi: 10.1186/gb-2009-10-9-r90

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Copyright © 2009 Cheng et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Differential expression of miRNA processing genes between ER⁺and ER^-breast cancer samples. (a) miRNA biogenesis and function pathway. Genes significantly up-regulated and down-regulated in ER^-compared to ER⁺samples are shown in yellow and cyan, respectively. A gene - for example, Drosha - is marked grey to denote that it shows no significant differential expression between ER^-and ER⁺samples. (b) Expression levels of Ago1, Ago2, Dicer, and TRBP in ER⁺(red) and ER^-(green) samples. The mean and the standard deviation of the expression levels for each gene are shown as a bar and vertical line, respectively. Data for a gene are not shown if it is missing from a dataset. The combined P-value for each gene is also shown.