Table 2.

Correlation between the results obtained using the ARR and RE-score calculation methods

	PITA			PicTar
Dataset	Percentage (ER- > ER+)	Percentage (ER- < ER+)	Spearman correlation	Percentage (ER- > ER+)	Percentage (ER- < ER+)	Spearman correlation
HE	58%	23%	0.861	77%	12%	0.752
MI	100%	0%	0.646	60%	16%	0.778
MN	73%	10%	0.668	62%	17%	0.763
VA	86%	2%	0.659	65%	5%	0.578
WA	68%	18%	0.855	59%	22%	0.837

Percentage (ER^- > ER⁺): the fraction of microRNAs with ARR < 1 and t-score < 0, indicating that the microRNAs show higher regulatory activity in ER^- than in ER⁺ samples, as consistently supported by both the ARR method and RE-score expression comparison method. Percentage (ER^- < ER⁺): the fraction of microRNAs with RR > 1 and t-score > 0. These microRNAs show higher regulatory activity in ER⁺ samples, as supported by both the ARR method and the RE-score expression comparison method. Spearman correlation: the correlation between the ARR value and t-score (ER^-/ER⁺).